Richard Piet
Biological Sciences
Assistant Professor
Campus:
Kent
Biography
Current research in the lab focuses on understanding the neurophysiological mechanisms involved in regulating the activity of the gonadotropin releasing hormone (GnRH) neurons and, ultimately, fertility in all mammals. We are particularly interested in the afferent control of GnRH neurons by kisspeptin neurons and in their regulation by circulating gonadal steroid hormones and by the circadian clock.
Education
Ph.D Neuroscience and Neuropharmacology, University Victor Segalen, Bordeaux, France
Research Methods
Patch-clamp electrophysiology
Live cell imaging
Optogenetics
Tract-tracing
Publications
- Jamieson BB, Bouwer GT, Campbell RE & Piet R (2021) Estrous cycle plasticity in the central clock output to kisspeptin neurons: Implications for the preovulatory surge. Endocrinology 162: bqab071
- Piet R*, Kalil B*, McLennan T, Porteous R, Czieselsky K & Herbison AE (2018) Dominant neuropeptide co-transmission in kisspeptin-GABA regulation of GnRH neuron firing driving ovulation. Journal of Neuroscience 38: 6310-6322. (*equal contribution)
- Clarkson J*, Han SY*, Piet R, McLennan T, Kane G, Ng J, Porteous R, Kim J, Colledge WH, Iremonger KJ & Herbison AE (2017) Definition of the hypothalamic GnRH pulse generator in mice. PNAS 114:E10216-E10223. (*equal contribution)
- Piet R, Fraissenon A, Boehm U & Herbison AE (2015) Estrogen permits vasopressin signaling in preoptic kisspeptin neurons in the female mouse. Journal of Neuroscience 35: 6881-6892.
- Piet R, Boehm U & Herbison AE (2013) Estrous cycle plasticity in the hyperpolarization-activated current Ih is mediated by circulating 17飦-Estradiol in preoptic area kisspeptin neurons. Journal of Neuroscience 33: 10828 鈥10839.
- Piet R, Garenne A, Farrugia F, Le Masson G, Marsicano G, Chavis P & Manzoni OJ (2011) State-dependent, bi-directional modulation of neural network activity by endocannabinoids. Journal of Neuroscience 31: 16591-16596.
- Piet R & Jahr CE (2007) Glutamatergic and purinergic receptor-mediated calcium transients in Bergmann glial cells. Journal of Neuroscience 27: 4027-4035.
- Piet R, Vargov谩 L, Sykov谩 E, Poulain DA & Oliet SH (2004) Physiological contribution of the astrocytic environment of neurons to intersynaptic crosstalk. PNAS 101: 2151-2155.
- Oliet SH, Piet R & Poulain DA (2001) Control of glutamate clearance and synaptic efficacy by glial coverage of neurons. Science 292: 923-926.
- For a full list of publications, please see https://www.ncbi.nlm.nih.gov/myncbi/richard.piet.1/bibliography/public/
Affiliations
- Brain Health Research Institute